Objective To discuss the application value of β-CTX,t-P1NP and N-MID-OT in the risk assessment of osteoporosis fractures in postmenopausal women.Methods A retrospective analysis was conducted on the clinical data of 102 postmenopausal osteoporosis(PMOP)patients who admitted to our hospital from Feb 2020 to Dec 2022,which were included in the study group;Based on the occurrence of fractures,the PMOP patients were divided into the PMOP fracture group 39 cases and the PMOP non fracture group 63 cases.Additionally,100 healthy individuals admitted to our hospital were selected as the control group.Record theβ-CTX,t-P1NP and N-MID-OT levels of all research subjects were compared and evaluated;Using receiver operating characteristic evaluate the application value of β-CTX,t-P1NP and N-MID-OT in the risk assessment of osteoporosis fractures in postmenopausal women.Results The average body weight,body mass index,femoral neck bone density(BMD),left hip total BMD,and L1-4 total BMD of the study group were significantly lower than those of the control group(P＜0.05);However,there was no statistically significant difference in average age,average height,and menopausal age between the two groups of study subjects(P＞0.05).The β-CTX(2.59±0.78)µg/L,t-P1NP(73.01±7.25)ng/mL and N-MID-OT(18.41±2.13)ng/mL of the study group were significantly higher than the control group(The values of t were 12.688,37.430 and 26.599 respectively,P＜0.05).The AUC value of β-CTX+t-P1NP+N-MID-OT combined detection for predicting PMOP was 0.978,the sensitivity was 98.04％and the specificity was 97.00％,which indicated that the combined detection of β-CTX+t-P1NP+N-MID-OT was more effective in predicting PMOP.The β-CTX(3.19±0.89)μg/L,t-P1NP(89.49±8.35)ng/mL and N-MID-OT(22.16±2.58)ng/mL of the PMOP fracture group were significantly higher than the PMOP unfractured group(The values of t were 6.078,16.363 and 12.227 respectively,P＜0.05).The AUC value of β-CTX+t-P1NP+N-MID-OT combined detection for evaluating the risk of PMOP fracture was 0.939,the sensitivity was 94.87％and the specificity was 95.24％,which indicated that the combined detection of β-CTX+t-P1NP+N-MID-OT was more effective in assessing the risk of PMOP fractures.Conclusion The β-CTX,t-P1NP and N-MID-OT levels of the PMOP patients were significantly elevated,while the β-CTX,t-P1NP and N-MID-OT levels of the PMOP fracture patients increased more significantly,and the combined detection of β-CTX+t-P1NP+N-MID-OT can significantly improve the effectiveness of PMOP prediction and fracture risk assessment,which is worth of reference.
维普
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