Objective To analyze the effects of comorbidity on the frailty of elderly patients with osteoporotic vertebral fractures,and to provide reference for improving the quality of life of patients with osteoporotic vertebral fractures.Methods Propensity score matching method was used to evaluate comorbidity and non-comorbidity in senile patients with osteoporotic vertebral fractures.Univariate analysis and multivariate logistic regression analysis were used to investigate the effects of comorbidity on the frailty of senile patients with osteoporotic vertebral fractures.Results The prevalence of comorbidity and frailty in senile patients with osteoporotic vertebral fractures was 46.4%and 42.1%,respectively.Logistic regression analysis showed that comorbidity was a risk factor for frailty in elderly patients with osteoporotic vertebral fractures(OR=18.373,P<0.001).In addition,gender,occupation,daily activity ability,nutritional risk,and hypertension were also influential factors for frailty in elderly patients with osteoporotic vertebral fractures(P<0.05).Conclusion Compared with those with non-comorbidity,patients with comorbidity of senile osteoporotic vertebral fractures have a higher risk of frailty.The quality of life management of senile osteoporotic vertebral fractures should be paid attention to.