With the increasing aging of society and population,people pay more and more attention to the harm caused by osteoporosis.Increased inflammation caused by oxidative stress and further induced ferroptosis are key risk factors for osteoporosis.Nuclear factor E2-related factor 2(Nrf2),as a key factor mainly regulating oxidative stress,can also regulate inflammation.Autophagy and ferroptosis constitute a regulatory network and are closely related to osteoporosis.At present,a large number of studies have confirmed that traditional Chinese medicine exerts various functions such as antioxidant and anti-inflammatory through Nrf2 regulatory network,and has obvious effects in the treatment of osteoporosis.By summarizing the correlation between Nrf2 regulatory network and osteoporosis and the research result of TCM intervention,this paper provides a new direction for the accurate prevention and treatment of osteoporosis by TCM in the future.
关键词
Nrf2/氧化应激/炎症/自噬/铁死亡/骨质疏松症/中医药
Key words
Nrf2/oxidative stress/inflammation/autophagy/ferroptosis/osteoporosis/traditional Chinese medicine
维普
万方数据