Imbalanced bone remodeling process is one of the important mechanisms in the development of osteoporosis,which is mainly due to the resorption of bone by osteoclasts exceeding osteoblast-mediated bone formation.NFATc1 has been shown to be involved in regulating the bone resorption process.The article reviews the signaling pathways and molecular mechanisms regulated by NFATc1 in osteoclasts,which are proposed to provide new therapeutic ideas and potential therapeutic targets for osteoporosis.The following conclusion have been obtained:(1)When the intervention of osteoclasts in the process of bone resorption exceeds that of osteoblasts,the imbalance in the process of bone remodeling occurs and osteoporosis may develop.(2)The key transcriptional regulation of NFATc1 in osteoclast resorption is through the RANKL-RANK,NF-κB,MAPK,and Ca2+signaling pathways,which regulate osteoclast generation and differentiation during bone metabolism,thereby mediating the imbalance between bone formation and bone resorption induced by osteoclast overgeneration.(3)The current anti-osteoporosis drug strategy does not have a very significant impact on the disease.(4)The research on the targeting of biomaterials to NFATc1 is in the initial stage and still needs to be explored thoroughly.
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