The relationship between major histocompatibility complex class Ⅱ molecules and postmenopausal osteoporosis
张桢 1陈昊 1王雪鹏 1朱六龙1
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作者信息
1. 浙江大学医学院附属杭州市第一人民医院骨科,浙江杭州 310006
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摘要
绝经后骨质疏松症(postmenopausal osteoporosis,PMOP)是由绝经期雌激素缺乏引起的骨代谢紊乱相关的全身性骨骼疾病.主要组织相容性复合体Ⅱ类分子(major histocompatibility complex Class Ⅱ molecules,MHC-Ⅱ)是蛋白质呈递途径的核心,其功能受雌激素调节,可通过参与由T和B淋巴细胞介导的适应性免疫反应,促进T细胞衍生各种炎症因子,最终促进破骨细胞介导的骨骼的骨形成和骨吸收.笔者就雌激素、MHC-Ⅱ、淋巴细胞及其在破骨细胞分化过程及功能活性中的潜在机制进行综述,进而更好地理解MHC-Ⅱ在绝经后骨质疏松症中的可能作用.
Abstract
Postmenopausal osteoporosis(PMOP)is a systemic skeletal disorder associated with disturbances in bone metabolism caused by estrogen deficiency during menopause.Major histocompatibility complex class Ⅱ molecules(MHC-Ⅱ),central to the protein presentation pathway,are regulated by estrogen and can participate in the adaptive immune response mediated by T and B lymphocytes and promote T cell-derived inflammatory factors,which ultimately promote osteoclast-mediated bone formation and bone resorption in the skeleton.In this paper,to better understand the possible role of MHC-Ⅱ in postmenopausal osteoporosis,we review estrogen,MHC-Ⅱ,and lymphocytes,and their potential mechanisms in the differentiation process and functional activity of osteoclasts.
关键词
绝经后骨质疏松症/雌激素/主要组织相容性复合体Ⅱ类分子/淋巴细胞/破骨细胞
Key words
postmenopausal osteoporosis/estrogen/major histocompatibility complex class Ⅱ molecules/lymphocytes/osteoclasts
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