Osteoporosis,characterized by decreased bone density,impaired bone microstructure,and increased risk of fractures,has gradually become a significant medical and socio-economic problem.Current treatment strategies primarily focus on symptom management but have not been able to fundamentally alter the course of the disease.Therefore,the search for and development of new therapeutic targets have emerged as an important direction in current research.P2X7,as an ion channel activated by extracellular ATP,has been found to play a crucial role in the growth,function,and survival of osteoblasts and osteoclasts in recent studies,holding immense potential for the treatment of osteoporosis.Consequently,P2X7 is poised to become a novel therapeutic target for osteoporosis.This review examines the role of P2X7 in osteoporosis and provides insights and directions for targeting this new therapeutic target,aiming to pave the way for the development of novel treatment strategies for osteoporosis.
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