Objective To explore the diagnostic value of the fracture risk assessment tools(FRAX)for carotid atherosclerosis in postmenopausal osteoporosis patients.Methods A total of 201 postmenopausal osteoporosis patients admitted to the first People's Hospital of Lianyungang from February 2019 to July 2023 were enrolled.Personal information collection,blood tests,carotid artery ultrasound examination,and dual-energy X-ray bone mineral density(BMD)examination were conducted on all subjects.All the participants were classified into two groups,the carotid atherosclerosis group(n=125)and the non-carotid atherosclerosis group(n=76).The ten-year probability of major osteoporotic fracture(PMOF),as well as the ten-year probability of hip fracture(PHF),was calculated with FRAX.Results Age and systolic blood pressure in the carotid atherosclerosis group were higher than those in the non-carotid atherosclerosis group(P＜0.05).There were no significant differences in blood lipid and bone metabolism markers between the two groups(P＞0.05).Participants in the carotid atherosclerosis group had lower BMD of the hip and femoral neck compared with those in the non-carotid atherosclerosis group(P＜0.05).PMOF and PHF were higher in the carotid atherosclerosis group(P＜0.05).Regression analysis showed that BMD of the hip and femoral neck was negatively correlated with carotid atherosclerosis(P＜0.05).PMOF and PHF were positively correlated with carotid atherosclerosis(P＜0.05).The above differences were still statistically significant after adjusting for confounding factors(P＜0.05).Receiver operating curve(ROC)analysis showed that PHF had the highest diagnostic value for carotid atherosclerosis,and the area under the curve was 0.775,while the area under the curve of PMOF was 0.773.Conclusion In postmenopausal osteoporosis patients,BMD of the hip and femoral neck is negatively correlated with carotid atherosclerosis,while PMOF and PHF are positively correlated with carotid atherosclerosis.FRAX exhibits good diagnostic value for carotid atherosclerosis.
维普
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