Osteoblasts are the primary cell types that encourage bone growth and maintain bone strength,and their aberrant function can directly result in the reduction of bone strength.A final event of cell metabolism is programmed cell death.Apoptosis,Autophagy,Ferroptosis,Pyroptosis,and Necroptosis are the five most prevalent forms of programmed cell death currently recognized.They exert their impact in various phases of cell metabolism in response to various stimuli,which is a requirement for the normal function of cells.They both cooperate and compete with one another.Osteogenesis and bone homeostasis could be kept in check through osteoblasts'programmed death.Therefore,it stands to reason that controlling osteoblasts'programmed death will directly affect how osteoporosis is treated.However,the crosstalk association with programmed osteoblast death is unclear.This article aims to review the role of osteoblast programmed death and its crosstalk association in osteoporosis,in order to provide new ideas and references for the study of regulating osteoblast death and alleviating osteoporosis.
维普
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