Osteoporosis is a degenerative disease caused by imbalance between bone absorption and bone formation.Peroxisome proliferation-activated receptors γ(PPARγ)can drive the occurrence and development of OP via Wnt/β-catenin,CEBPα and OPG/RANKL/RANK signal pathways.Research has found that traditional Chinese medicine can target PPAR γ Regulating these signaling pathways,promoting the formation of osteoblasts,inhibiting the absorption of osteoclasts,and thus exerting anti osteoporosis effects.This article indexed databases such as PubMed,CNKI,Wanfang,and VIP,which have included information on how traditional Chinese medicine inhibits PPARγ over the past decade.Summarize and conclude the research literature on the prevention and treatment of osteoporosis,in order to provide reference for in-depth research on traditional Chinese medicine treatment of osteoporosis.
关键词
骨质疏松症/中药/PPARγ/成骨细胞/破骨细胞
Key words
osteoporosis/traditional Chinese medicine/PPARγ/osteoclast/osteoblast
维普
万方数据