摘要
清道夫受体(scavenger receptors,SR)是表达于髓样细胞上功能多样的蛋白质,不仅具有清除修饰脂蛋白、识别并结合配体的能力,而且作为先天模式识别受体之一,在生物学过程中发挥着重要作用.因此,SR不仅对于维持宿主体内平衡起着关键作用,而且还参与了许多疾病的发病机制.类风湿关节炎(rheumatoid arthritis,RA)的特征是炎性细胞浸润和关节滑膜炎的发生,滑膜炎中最显著的细胞是巨噬细胞,活化的巨噬细胞能够产生多种细胞因子,最终导致软骨和骨的严重破坏.近期研究发现,SR-A作为SR的分类之一,在RA的发病过程中起着关键性作用,本文就SR-A在RA中的作用及其应用研究进展作一综述,以期能够为临床诊断及治疗RA提供新思路、新方法.
Abstract
Scavenger receptors(SRs)are functionally diverse proteins expressed on myeloid cells.SRs not only have the ability to clear modified lipoproteins,recognize and bind ligands,but also play an important role in biological processes as one of the innate pattern recognition receptors.Therefore,SRs not only play a key role in maintaining host homeostasis,but also are involved in the pathogenesis of many diseases.Rheumatoid arthritis(RA)is characterized by inflammatory cell infiltration and the development of joint synovitis.The most prominent cell of synovitis is macrophages.Activated macrophages are capable of producing a variety of cytokines,ultimately leading to severe destruction of cartilage and bone.Recent studies have found that SR-A,as one of the classifications of SRs,plays a key role in the pathogenesis of RA.This article reviews the role of SR-A in RA and its application research progress,in order to provide new ideas and methods for the clinical diagnosis and treatment of RA.
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