Antimicrobial peptide(AMPS)is a host defense peptide.Its antibacterial and antiviral effects are paid attention in previous studies.Further studies have shown that cathelicidin LL-37 regulates bone metabolism through multiple pathways and participates in the occurrence and development of osteoporosis,such as osteogenesis,osteoclast,immunity,and promoting angiogenesis.This article reviews the mechanism of LL-37 in bone metabolism and its influence in osteoporosis,aiming to explore the relationship between AMPS and osteoporosis and to provide theoretical basis for the treatment of osteoporosis with AMPS.
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