Correlation between serum uric acid/high-density lipoprotein ratio and bone mineral density in hospitalized patients with spinal degeneration
汪青 1黄昊强 1周宇 1陈勇 1林华 2彭志坚1
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作者信息
1. 昆山市中医医院,江苏昆山 215300
2. 南京大学附属鼓楼医院骨代谢病中心,江苏南京 210008
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摘要
目的 探索脊柱退变住院患者血清尿酸/高密度脂蛋白比值与骨密度的相关性.方法 共纳入803例脊柱退变的受试者,评估临床因素及实验室检查结果,测量骨密度,按照骨密度结果分为骨质疏松症组及非骨质疏松症组.采用多元Logistic回归分析血清尿酸/高密度脂蛋白比值(uric acid to high-density lipoprotein cholesterol ratio,UHR)与骨质疏松症的相关性.结果 与非骨质疏松症组相比,骨质疏松症组的UHR更低(244.93±.102.51 vs 199.97±.91.96,P＜0.001),多元Logistics回归分析提示,在校正了骨质疏松症的传统危险因素后,UHR最高的四分位患者发生骨质疏松症的可能性是UHR最低的四分位患者的0.402倍(P=0.018).骨质疏松症的患病率在UHR四分位呈下降的趋势,骨密度在UHR四分位呈升高的趋势.UHR在骨量正常、骨量减少及骨质疏松症3组呈下降的趋势.结论 低UHR是昆山地区脊柱退变住院患者发生骨质疏松症的危险因素.对于UHR较低的脊柱退变患者,应注意筛查骨质疏松症.
Abstract
Objective To explore the correlation between serum uric acid/High-density lipoprotein ratio and bone mineral density in hospitalized patients with spinal degeneration.Methods A total of 803 subjects with spinal degeneration were included.Clinical factors and laboratory tests were evaluated,and bone density was measured.According to the bone density result,they were divided into osteoporosis group and non osteoporosis group.Multivariate logistic regression was used to analyze the correlation between serum uric acid to High-density lipoprotein cholesterol ratio(UHR)and osteoporosis.Results Compared with the non osteoporosis group,the UHR of the osteoporosis group was lower(244.93±102.51 vs 199.97±91.96,P＜0.001).Multiple logistic regression analysis showed that after adjusting for traditional risk factors for osteoporosis,the possibility of osteoporosis in the highest quartile of UHR patients was 0.402 times higher than that in the lowest quartile of UHR patients(P=0.018).The incidence of osteoporosis showed a decreasing trend in the fourth quartile of UHR,while bone density showed an increasing trend in the fourth quartile of UHR.UHR showed a decreasing trend in the three groups of normal bone mass,decreased bone mass,and osteoporosis.Conclusion Low UHR is a risk factor for osteoporosis in hospitalized patients with spinal degeneration in Kunshan area.For patients with spinal degeneration with lower UHR,attention should be paid to screening for osteoporosis.
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