Osteoarthritis(OA)represents a chronic joint disorder,predominantly exhibiting cartilage degeneration,synovial inflammation,and deterioration of joint function.The pathological progression involves critical roles of inflammatory reactions and an over-release of inflammatory cytokines.lipoxin A4(LXA4),a lipid mediator with pronounced anti-inflammatory characteristics,exhibits intrinsic anti-inflammatory and immunomodulatory effects in the onset of OA.Recent studies have unveiled that physical activity,serving as a non-drug therapeutic strategy for OA,notably modulates LXA4 levels and inflammatory reactions.LXA4 is capable of suppressing NF-κB and p38-MAPK signaling,mitigating inflammation and pain associated with OA.Physical activity activates 12-lipoxygenase(12-LOX)and lipid oxidation pathways,bolsters LXA4 synthesis,and further,diminish levels of inflammatory cytokines by interaction with synovial fibroblasts,macrophages,and neutrophils.The intensity and frequency of exercise also impart an impact in LXA4 levels and the therapeutic efficacy for OA.Moderate to high-intensity exercise notably excels in elevating LXA4 levels and inhibits inflammatory factors.However,high-intensity exercise may exert negative effects on cartilage.At present,the optimal exercise regimen involves 20-30 minutes per session,2-3 sessions daily,with a 4-hour interval,exhibiting outstanding result in diminishing enzymes related to cartilage breakdown and optimizing cartilage tissue structure.
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