Osteoarthritis(OA)is a common chronic degenerative disease with progressive destruction of articular cartilage as its main pathological feature.Studies have confirmed that the dysfunction of chondrocytes in cartilage tissue is a key factor in the progression of OA,including the abnormal activation of energy metabolism,biological clock,autophagyand apoptosis,and the increase of senescent chondrocytes.Silencing message regulators(sirtuin)are a family of niacinamide and niacinopine dinucleotide-dependent deacetylasesthat delay the progression of OA by participating in and regulating protein deacetylationduring chondrocyte function.According to literature reports,this paper will focus on the regulatory mechanism of SIRT family members on the function of OA chondrocytes,aiming to further understand the mechanism of SIRT family in OA chondrocytes andprovide ideas for future targeted treatment of OA.
维普
万方数据