淫羊藿苷修复骨缺损及其作用机制研究
Research progress of icariin in repairing bone defect and its mechanism of action
杨世超 1宋慕格 1李幸 2王立强 1安梓栋 1柏鑫 1魏振龙 3高玉海 3陈克明4
作者信息
- 1. 中国人民解放军联勤保障部队第九四○医院基础医学实验室,甘肃兰州 730050;甘肃中医药大学中医临床学院,甘肃兰州 730000
- 2. 中国人民解放军联勤保障部队第九四○医院基础医学实验室,甘肃兰州 730050
- 3. 中国人民解放军联勤保障部队第九四○医院基础医学实验室,甘肃兰州 730050;甘肃省干细胞与基因药物重点实验室,甘肃兰州 730050
- 4. 中国人民解放军联勤保障部队第九四○医院基础医学实验室,甘肃兰州 730050;甘肃中医药大学中医临床学院,甘肃兰州 730000;甘肃省干细胞与基因药物重点实验室,甘肃兰州 730050
- 折叠
摘要
骨缺损治疗一直是困扰骨科的一大难题,由于骨的再生能力有限,大面积的骨缺损常无法自行愈合.淫羊藿苷(icariin,ICA)在骨形成方面的效果明显,淫羊藿含有的ICA是一种黄酮类化合物和活性化合物,具有促进骨形成和抑制骨吸收的双重活性,并且可以通过多种生物材料进行局部递送,促进骨缺损修复,展现出良好的的骨诱导潜力.研究发现,ICA主要通过促进骨形成、软骨形成、血管生成、抑制骨吸收和抗炎作用修复骨缺损.本文就ICA修复骨缺损及其作用机制加以概述,以期为后续研究提供一定参考.
Abstract
The treatment of bone defects has always been a major problem in orthopedics.Due to the limited regenerative capacity of bone,large-scale bone defects often cannot be healed by themselves.Icariin(ICA)has an obvious effect on bone formation.ICA contained in Icariin is a flavonoid compound and an active compound,which has dual activities of promoting bone formation and inhibiting bone absorption.Icariin can also be delivered locally through a variety of biological materials to promote bone defect repair,showing a good bone induction potential.It has been found that ICA mainly repairs bone defects by promoting bone formation,cartilage formation,angiogenesis,and by inhibiting bone resorption and anti-inflammatory effects.In this paper,ICA repair of bone defect and its mechanism of action are summarized in order to provide some reference for the follow-up research.
关键词
淫羊藿苷/骨缺损/成骨细胞/骨形成/作用机制Key words
icariin/bone defect/osteoblast/bone formation/action mechanism引用本文复制引用
基金项目
甘肃省自然科学基金(22JR5RA020)
军队后勤自主科研项目(2023HR22-07)
联勤保障部队第九四○医院实验室培育项目(2021yxky081)
兰州市科技计划(2003-8-1)
出版年
2024
NETL
NSTL
万方数据