中医药通过NF-κB信号通路治疗骨关节炎的研究进展
The research progress of traditional Chinese medicine regulate NF-κB signaling pathway in the treatment of osteoarthritis
刘江燕 1张晓峰 1徐西林 2李朝霞 1段洪超3
作者信息
- 1. 黑龙江中医药大学,黑龙江哈尔滨 150040
- 2. 黑龙江中医药大学附属第三医院,黑龙江哈尔滨 150016
- 3. 黑龙江中医药大学附属第二医院,黑龙江哈尔滨 150001
- 折叠
摘要
随着全球人口老龄化的进展,骨关节炎的发病率也逐年上升,必将成为一大社会公共卫生问题.骨关节炎发病机制复杂,中药因其多成分、多途径、多靶点的特点在治疗骨关节炎方面具有巨大潜力.大量研究表明中医药可通过调节NF-κB信号通路抑制炎症反应、氧化应激、基质降解、细胞凋亡等治疗骨关节炎.本文综述了中医药通过NF-κB通路治疗骨关节炎的研究进展,以期为未来的基础和临床研究提供参考.
Abstract
With the progress of global aging,the incidence rate of osteoarthritis is also increasing year by year,which will become a main social and public health problem.The pathogenesis of osteoarthritis is complex.Traditional Chinese medicine has great potential in the treatment of osteoarthritis because of its multi-component,multi-channel and multi target characteristics.Numerous studies have shownthat traditional Chinese medicine can regulate NF-κ B signaling pathway inhibits inflammatory response,oxidative stress,matrix degradation,cell apoptosis and so on to treat osteoarthritis.This article reviews the research progress of traditional Chinese.medicine regulate NF-κB signaling pathway in the treatment of osteoarthritis,which expecting to provide reference for future basic and clinical research.
关键词
NF-κB/骨关节炎/氧化应激/炎症反应/发病机制Key words
NF-κB/osteoarthritis/oxidative stress/inflammatory response/pathogenesis引用本文复制引用
基金项目
国家自然科学基金(81774343)
全国名老中医药专家传承工作室建设项目(2021-2024)()
黑龙江中医药局中医药科研项目(2023)(ZHY2023-045)
中央支持地方高校改革发展资金人才培养项目(2019)()
出版年
2024
NETL
NSTL
万方数据