胞葬在骨稳态调控中的作用及研究进展
The role of efferocytosis in the regulation of bone homeostasis and its research progress
拦玉鑫 1马小成 1刘德孙 1张勇杰 1胡康一 1尚征亚 1杨小瑞 1曹林忠2
作者信息
- 1. 甘肃中医药大学,甘肃 兰州 730000
- 2. 甘肃中医药大学,甘肃 兰州 730000;甘肃中医药大学附属医院,甘肃 兰州 730000
- 折叠
摘要
骨稳态是破骨细胞骨吸收与成骨细胞骨形成动态调节的过程,是人体骨骼正常发育的基础,骨稳态失衡影响着骨代谢相关疾病的发生和发展.然而,骨稳态的调节机制较为复杂,至今尚未完全阐明.近年研究发现,成骨细胞、破骨细胞及骨髓间充质干细胞胞葬在骨稳态的调节过程中发挥着至关重要的作用.胞葬能够维持成骨细胞、破骨细胞及骨髓间充质干细胞的正常功能,促进骨稳态,抑制骨质流失,增强骨骼强度.笔者就胞葬的发生机制进行阐述,对成骨细胞、破骨细胞及骨髓间充质干细胞胞葬与骨稳态的关系进行总结,以期为调节骨稳态,防治骨代谢相关疾病的研究提供新角度.
Abstract
Bone homeostasis is a dynamic regulation process of bone resorption by osteoclasts and bone formation by osteoblasts.It is the basis for the normal development of human bones.The imbalance of bone homeostasis affects the occurrence and development of many orthopedic diseases.However,the regulatory mechanism of bone homeostasis is relatively complex and has not yet been fully elucidated.In recent years,research has found that osteoblasts,osteoclasts,and bone marrow mesenchymal stem cells play a crucial role in regulating bone homeostasis.Efferocytosis maintains the normal function of osteoblasts,osteoclasts,and bone marrow mesenchymal stem cells,promotes bone homeostasis,inhibits bone loss,and enhances bone strength.In this paper,the mechanism of efferocytosis is elaborated,and the relationship between osteoblasts,osteoclasts and bone marrow mesenchymal stem cells efferocytosis and bone homeostasis is summarized,in order to provide a new perspective for the study of regulating bone homeostasis and preventing and treating bone metabolism-related diseases.
关键词
胞葬/骨稳态/成骨细胞/破骨细胞/骨髓间充质干细胞Key words
efferocytosis/bone homeostasis/osteoblasts/osteoclasts/bone marrow mesenchymal stem cells引用本文复制引用
基金项目
国家自然科学基金(81860859)
国家自然科学基金(82160915)
兰州市科技局项目(2022-3-23)
出版年
2024
NETL
NSTL
万方数据