"miRNA-肠道微生物群"功能轴对骨质疏松症的影响机制
Exploration of the mechanism of osteoporosis based on the functional axis of miRNA-intestinal microbiota
胡丹 1杨欣 1李娟 2张浩令3
作者信息
- 1. 重庆医科大学附属第一医院护理部,重庆 400016
- 2. 重庆医科大学附属第一医院教务处,重庆 400016
- 3. 马来西亚理科大学高级医学和牙科研究所,马来西亚 槟城 13200
- 折叠
摘要
骨质疏松症(osteoporosis,OP)是一种以骨质减少、骨微结构破坏为特征的系统性骨病,其发病机制涉及遗传、环境和生物多种因素的相互作用.近年来,微小RNA(miRNA)与肠道微生物群(gut microbiota,GM)在其中的影响越来越引人关注.miRNA通过调控成骨细胞介导的骨形成和破骨细胞介导的骨吸收干预OP的进程,而GM则通过调节免疫反应、代谢功能、激素平衡等多重途径影响骨代谢.笔者旨在深入剖析"miRNA-肠道微生物群"功能轴对OP的作用机制,为OP的预防和治疗提供参考依据.
Abstract
Osteoporosis,a systemic bone disease characterized by bone loss and destruction of bone microstructure,is driven by a complex interplay of genetic,environmental,and biological factors.Recently,miRNA and intestinal microbiota have emerged as key factors in the pathogenesis of osteoporosis,garnering increasing attention.Specifically,miRNA influences osteoporosis development by modulating osteoblast-mediated bone formation and osteoclast-mediated bone resorption,while intestinal microbiota impacts bone metabolism through the regulation of immune response,metabolic function,hormone balance,and other complex pathways.This article aims to analyze the functional axis of the miRNA-intestinal microbiota in osteoporosis,shedding light on its mechanism and providing valuable insights for the prevention and treatment of osteoporosis.
关键词
miRNA/肠道微生物群/骨质疏松症/骨代谢Key words
miRNA/intestinal microbiota/osteoporosis/bone metabolism引用本文复制引用
基金项目
甘肃省教育科技创新项目(2022A-067)
甘肃省高等学校创新基金(2023A-088)
甘肃省自然科学基金(22JR5RA582)
甘肃省科技计划项目重点研发计划国际科技合作类(23YFWA0005)
重庆医科大学未来医学青年创新团队支持计划(W0019)
出版年
2024
NETL
NSTL
万方数据