骨小梁分数在成都地区人群中变化及临床应用精确度评估
Changes of trabecular bone score in the population of Chengdu and assessment of the precision in clinical application
高海燕 1张伟 1郑洪银 1肖翊 1黄际远1
作者信息
- 1. 四川省医学科学院·四川省人民医院(电子科技大学附属医院)核医学科,四川 成都 610072
- 折叠
摘要
目的 观察骨小梁分数(trabecular bone score,TBS)在成都地区人群中的分布及变化;评估TBS用于骨质疏松症治疗监测的精确度.方法 选择2022 年10 月至2023 年7 月在四川省医学科学院·四川省人民医院就诊或体检者4 963 例,其中女性 3 708 人,男性 1 255 人,均行双能X线(DXA)检查测量腰椎TBS及骨密度(bone mineral density,BMD),结果以均值±标准差(SD)表示.选取 30 例患者每人行两次DXA检查,计算BMD、TBS的精确度误差.结果 ①TBS在男性 20～29 岁、女性 30～39 岁时达到峰值,之后均随增龄逐渐下降;②男、女TBS与年龄呈负相关,与体质量指数(body mass index,BMI)呈弱正相关;TBS与L1～4 BMD呈正相关;③低骨量组男、女TBS受损者占比分别为19.6%、35.1%;BMD正常TBS受损+部分受损者占比分别为 22.9%、40.5%.L1～4 BMD的CV%和LSC-CV%分别为 1.089%、3.015%;TBS的CV%和LSC%分别为 1.429%、3.958%.结论 ①本组TBS数据为成都地区人群骨质疏松防治、骨折风险评估提供了参考依据,随增龄BMD、TBS逐渐丢失,以女性更为明显;②TBS有较好的精确度,可用于骨质疏松症的治疗监测.
Abstract
Objective To observe the distribution and changes of trabecular bone score(TBS)in the population of Chengdu region.To evaluate the precision of TBS for monitoring osteoporosis treatment.Methods A total of 4 963 patients,including 3 708 females and 1 255 males were selected from October 2022 to July 2023.Dual energy X-ray Absorptiometry(DXA)examination were performed to measure lumbar BMD and TBS.The result were expressed as mean±standard deviation(SD).30 patients were selected to undergo two DXA examinations each.The precision errors of BMD and TBS were calculated.Results ①The TBS reaches its peak in males aged 20-29 and females aged 30-39,and Gradually decreases with age thereafter.② TBS were negatively correlated with age and weakly positively correlated with BMI both in male and female.TBS was positively correlated with L1-4 BMD.③The proportion of degraded TBS in male and female in low bone mass group were 19.6%and 35.1%,respectively;The proportion of degraded or partially degraded TBS in men and women with normal BMD were 22.9%and 40.5%,respectively.The CV%and LSC-CV%of L1-4 BMD were 1.089%and 3.015%,respectively;and in TBS were 1.429%and 3.958%,respectively.Conclusion ①This group of TBS data provided a reference basis for treatment of osteoporosis and the risk assessment of fractures for the population in Chengdu region.BMD and TBS gradually losed with age,especially in women.②TBS has good precision and can be used for monitoring the treatment of osteoporosis.
关键词
骨小梁评分/双能X射线吸收法/骨密度/精确度误差Key words
dual-energy X-ray absorptiometry/trabecular bone score/bone density/precision error引用本文复制引用
基金项目
四川省医学科学院·四川省人民医院临床研究及转化基金(2017LY01)
出版年
2024
NETL
NSTL
万方数据