摘要
目的 探讨常规CT中胸椎椎体骨质定量与冠脉及胸主动脉钙化相关性.方法 收集 217 例患者一般资料、生化指标及冠脉CTA.测量冠脉、胸主动脉钙化积分,分为钙化组与非钙化组.测量T6～11 椎体松质骨及皮质骨密度,椎体骨赘积分.进行组间比较、相关分析及回归分析.结果 冠脉与胸主动脉钙化组年龄、收缩压、血糖及骨赘积分均高于非钙化组,松质骨密度低于非钙化组(P＜0.05).冠脉钙化积分与年龄、收缩压、血糖、皮质骨密度及骨赘积分正相关,与松质骨密度负相关(P＜0.05).胸主动脉钙化积分与年龄、收缩压及骨赘积分正相关,与松质骨密度负相关(P＜0.05).回归分析示年龄、收缩压、血糖及骨赘积分是冠脉钙化的独立风险因素,年龄、收缩压及骨赘积分是胸主动脉钙化的独立风险因素(P＜0.05).ROC曲线示联合应用各独立风险因素能提高对冠脉及胸主动脉钙化风险的预测价值.结论 椎体骨赘积分增高和松质骨密度减低与冠脉及胸主动脉钙化显著相关.
Abstract
Objective To explore the correlation between the bone quantification of the thoracic vertebral and calcification of the coronary artery and thoracic aortic with routine CT.Methods General information,biochemical indexes,and coronary CTA of 217 patients were collected.Coronary and thoracic aorta calcification scores were measured and divided into calcified and non-calcified group.Cancellous and cortical bone mineral density,osteophyte score of T6-11 were measured.Comparisons,correlation analyses,and regression analyses between the groups were conducted.Results Calcified group of coronary and thoracic aorta had higher age,systolic blood pressure(SBP),blood glucose,and osteophyte scores.Calcified group had lower cancellous bone mineral density(P＜0.05).Coronary calcification scores correlated positively with age,SBP,blood glucose,cortical bone mineral density,and osteophyte scores,and negatively with cancellous mineral bone density(P＜0.05).Thoracic aorta calcification scores correlated positively with age,SBP,and osteophyte scores,and negatively with cancellous bone mineral density(P＜0.05).Regression analysis showed that age,SBP,blood glucose,and osteophyte scores were independent risk factors for coronary artery calcification,and age,SBP,osteophyte scores were independent risk factors for thoracic aortic calcification(P＜0.05).ROC curve showed that the combination of the independent risk factors improved the predictive value of coronary and thoracic aorta calcification risk.Conclusion Increased osteophyte score and decreased cancellous bone mineral density are significantly associated with coronary artery and thoracic aorta calcification.
基金项目
山东省重点研发计划项目(2018GSF118140)
淄博市医药卫生科研项目(20230901079)
NETL
NSTL
万方数据