BRD4及其抑制剂在骨相关疾病中的研究进展
Research progress of BRD4 and its inhibitors in bone-related diseases
李磊 1张广智 1杨智立 1康学文1
作者信息
- 1. 兰州大学第二医院骨科,甘肃 兰州 730030;甘肃省骨关节疾病重点实验室,甘肃 兰州 730030
- 折叠
摘要
溴结构域蛋白 4(bromodomain-containing protein 4,BRD4)是溴结构域和超末端结构域家族的成员,在调节基因转录、细胞增殖、凋亡和炎症方面发挥着重要作用.BRD4 与各种疾病密切相关,包括癌症、神经系统疾病和病毒感染.虽然 BRD4 在癌症研究领域引起了广泛的关注,但是关于它在骨相关疾病中的影响,包括骨关节炎、椎间盘退变、骨质疏松和骨肿瘤等方面的研究还很有限.最近的研究表明 BRD4 参与骨相关疾病的发病机制,突出其重要作用.因此,笔者综述了近年来 BRD4 及其抑制剂在骨相关疾病中的研究进展.通过阐述 BRD4 的结构和功能以及 BRD4 及其抑制剂在骨相关疾病中的作用,提示BRD4 可能是治疗骨相关疾病的潜在靶点.
Abstract
Bromodomain-containing protein 4(BRD4)is a member of the bromodomain and extraterminal domain family,playing a crucial role in the regulation of gene transcription,cell proliferation,apoptosis,and inflammation.BRD4 has been closely linked to various diseases,including cancer,neurological disorders,and viral infections.Although BRD4 has obtained significant attention in the field of cancer research,limited investigation has been conducted regarding its implications in bone-related diseases,encompassing osteoarthritis,intervertebral disc degeneration,osteoporosis,and bone tumors,among others.Recent research has indicated the involvement of BRD4 in the pathogenesis of bone-related diseases,highlighting its significant role.Therefore,this review summarizes the research result of BRD4 and its inhibitors in bone-related diseases in recent years.By expounding the structure and function of BRD4 and the role of BRD4 and its inhibitors in bone-related diseases,it is suggested that BRD4 may be a potential target for the treatment of bone-related diseases.
关键词
BRD4/骨关节炎/椎间盘退变/骨质疏松/骨肿瘤/抑制剂Key words
BRD4/osteoarthritis/intervertebral disc degeneration/osteoporosis/bone tumors/inhibitors引用本文复制引用
基金项目
国家自然科学基金(82272536)
甘肃省自然科学基金优秀博士生计划项目(22JR5RA949)
兰州大学创新创业培育项目(cxcy2023012)
出版年
2024
NETL
NSTL
万方数据