Objective To observe the intervention of acupoint pressure stimulation patch combined with denosumab in postmenopausal osteoporosis(PMOP)patients and to evaluate its clinical efficacy.Methods A total of 110 postmenopausal patients with osteoporosis were randomly divided into two groups,with 55 cases in each group.Patients in the control group received disuzumab,calcitriol,and calcitral intervention.Patients in the experimental group received additional acupoint pressure stimulation patch on the basis of the control group.Quantitative CT bone mineral density(qctBMD),bone metabolism level of serum type Ⅰ procollagen N-terminal peptide(PINP)and type Ⅰ collagen cross-linked C-terminal peptide(β3-CTX),low back pain score(VAS),and TCM symptomatology score were observed and compared between control group and experimental group before treatment and 6 months after treatment.Results Six cases fell off in the control group and 4 cases fell off in the experimental group.Eventually,100 patients completed the clinical trial.① BMD:BMD in the control group and the experimental group gradually increased after 6 months of treatment(P＜0.05).BMD in the experimental group was significantly higher than that in the control group(P＜0.05).②Bone metabolism level PINP:serum PINP level in the control group and the experimental group decreased significantly after 6 months of the treatment compared to that before treatment(P＜0.05).The reduction of PINP in the experimental group was lower than that in the control group(P＜0.05).Bone metabolism level β-CTX:after 6 months of the treatment,β3-CTX decreased significantly in both control group and experimental group compared to that before treatment(P＜0.05).There was no significant difference between the two groups before(P＞0.05).③VAS score:in the control group,the VAS score of low back pain decreased significantly after 6 months of the treatment(P＜0.05).There was no significant difference between the two groups(P＞0.05).④TCM symptomatology scores:the lumbar and dorsal VAS scores in the control group and experimental group were significantly lower than those before the treatment at 6 months(P＜0.05).VAS scores in the experimental group was significantly lower than those in the control group(P＜0.05).Conclusion Acupoint pressure stimulation patch combined with denosumab in the treatment of postmenopausal osteoporosis significantly improves BMD and bone metabolism,reduces back pain and symptoms of traditional Chinese medicine.It is superior to the control group in improving BMD,PINP,and symptoms of traditional Chinese medicine.However,at present,there is no evidence that the combination of acupressure stimulation patch has an advantage over denosumab alone in improving β3-CTX and low back pain.
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