Percutaneous kyphoplasty(PKP)greatly relieves the pain after osteoporotic vertebral compression fracture(OVCF).However,many patients still retain some of the original pain after surgery,and are even at risk of refracture of the injured vertebra and adjacent vertebral fractures.At present,there are different views on the risk factors of postoperative residual pain and related complications of OVCF.It is a novel idea and method to explore the pathogenesis from the perspective of postoperative residual stress.Residual stress is the internal force that remains after the external force is removed from the material.The generation of this force can be divided into external causes and internal causes of uneven internal organizational structure of the material.Its presence may lead to decreased vertebral strength and mechanical properties,which in turn affect symptoms such as pain in OVCF patients after PKP.From the perspective of residual stress,this paper discusses the reasons why the pain and other symptoms of OVCF patients can not be completely relieved after PKP,and summarizes the disadvantages of stress concentration and how to prevent and balance residual stress from the distribution of bone cement.This can better guarantee the quality of life of OVCF patients after PKP.The proposed residual stress not only provides a new prevention and treatment strategy for OVCF patients after PKP,but also provides a new physiotherapy idea for other postoperative residual pain and other symptoms.Taking this as a starting point,it will be a new direction of biomechanics research and has a role that cannot be ignored in clinic.