PANoptosis,also known as panapoptosis,represents a distinctive form of cell demise characterized by the simultaneous occurrence of pyroptosis,apoptosis and necrosis within the same cellular population.This burgeoning field of investigation has garnered considerable scholarly interest due to its fundamental nature as a finely orchestrated and harmoniously balanced program of inflammatory cell death,amalgamating key traits of pyroptosis,apoptosis,and necrosis.The intricate interplay between osteoporosis and the regulation of bone homeostasis,often referring to bone balance,has been particularly associated with the formation of the PANoptosome.The PANoptosome is an indispensable cellular structure whose assembly and activation exhibits a strong correlation with systemic degenerative and inflammatory ailments,notably including osteoporosis.Consequently,this exists an immediate need for a comprehensive understanding of the mechanisms and controls governing PANoptosis,as well as the intricate relationship between PANoptosis and osteoporosis.This article provides a thorough exploration of both the distinctions and parallels between PANoptosis and the three well-established modes of cell demise:pyroptosis,apoptosis,and necrosis.The central focus is directed towards elucidating the molecular mechanisms and regulatory patterns of PANoptosis,with the ultimate goal of advancing further investigations into the regulatory framework of PANoptosis in the context of osteoporosis.
维普
万方数据