The dysfunction of bone formation mediated by osteoblasts is the pathological basis of common bone metabolism-related diseases in the elderly.Studies have shown that signaling pathways such as late end product receptor(RAGE),mitogen-activated protein kinase(MAPK),TOLL-like receptor 4/nuclear transcription factor-KB(TLR 4/NF-κB),and Wnt/β-catenin(Wnt/β-catenin)have the ability to regulate osteoblasts and maintain bone homeostasis.HMGB 1,as a cytokine,participates in inflammatory response and plays an important role in regulating osteoblast proliferation and differentiation and in maintaining bone homeostasis.Therefore,by summarizing the current research status of the above signaling pathway and HMGB 1 intervention in osteoblasts,this paper aims to provide new ideas for osteoblast-related research and to provide theoretical reference and basis for promoting bone formation and maintaining bone homeostasis.
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