Rheumatoid arthritis(RA)is a chronic inflammatory joint disease mediated by autoimmune abnormalities,characterized by synovial inflammation and irreversible bone erosion,which is associated with abnormal bone immune system function.Bone loss is a typical consequence of RA.Local bone loss can lead to erosive changes in inflamed joints,while systemic bone loss can lead to secondary osteopenia or obvious osteoporosis(OP).Osteoimmunology is defined as a new interdisciplinary field involving the interaction between the skeletal system and the immune system,including osteoclasts,osteoblasts,immune cells,etc.This article reviews relevant domestic and foreign literature and reviews the substantial progress made in the pathophysiology of OP secondary to RA based on the bone immune system,in order to provide reference for the prevention of RA and anti OP.
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