Objective To evaluating the relationship between oxidation balance score(OBS)and sarcopenia.Methods The analysis was based on data from 8,156 participants from the 2011-2018 National Health and Nutrition Examination Survey in the United States.OBS was calculated comprehensively based on 16 dietary factors and 4 lifestyle factors.Sarcopenia was determined by the ratio of appendicular skeletal muscle mass to body mass index.Weighted multivariate logistic regression analysis and restricted cubic splines were used to explore the relationship between OBS and sarcopenia.Subgroup analyses were used to explore the effect of gender on both.Results Among all participants,OBS,dietary OBS,and lifestyle OBS were negatively associated with sarcopenia.Compared to the lowest quartile group,the highest quartile group of OBS,dietary OBS,and lifestyle OBS had the risk of sarcopenia reduced by 69%[0.31(0.21,0.47)],56%[0.44(0.30,0.63)],and 64%[0.36(0.24,0.53)]respectively.Restricted cubic splines further demonstrated the nonlinear relationship between OBS,dietary OBS,and lifestyle OBS with sarcopenia.Conclusion The negative association between OBS and sarcopenia suggested that adhering to an antioxidant-rich diet and lifestyle may help prevent sarcopenia.