Exosomes are a specialized vesicle secreted by cells that can transmit information molecules from the cells.Exosomes act as messengers in cell-to-cell signal transmission and play an important role in angiogenic coupling.Exosomes interact with cells through itself or self-contained various factors such as microRNA and signal transducer and activator of transcription,regulate the generation of blood vessels and bone regeneration,and then regulate the process of osteogenic coupling.Current research of exosomes is mostly from mesenchymal stem cells,tumor cells,macrophages,endothelial progenitor cells,etc.It has great potential in the treatment of vascular-related bone diseases.The recent domestic and foreign related literature on the role of exosomes in angiogenesis are widely reviewed and summarized in this note.We hope to provide reference for the subsequent studies on the coupling effect of exosomes and angiogenesis,and to provide ideas for finding new targets for the treatment of vascular-related bone diseases.
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