Osteoporosis(OP)is a common systemic bone metabolic disease clinically,mainly induced by the imbalance or deviation of bone homeostasis caused by various factors.Abundant research has confirmed that long non-coding RNA(lncRNA),such as lncRNA XIST,plays a crucial role in the metabolic imbalance processes of OP,such as bone homeostasis imbalance or deviation,proliferation and apoptosis of chondrocytes,and interactions between miRNA and proteins.This may provide a new perspective for in-depth exploration of the pathogenesis of OP.This article aims to review the relevant studies of lncRNA XIST in OP,in order to reveal its key mechanisms in the occurrence and development of OP,and provide theoretical support for the clinical treatment of bone metabolic diseases using lncRNA XIST.
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