Bamboo-C software is an advanced PWR fuel management software based on the"two-step"neutron calculation strategy.This paper introduces the application of Bamboo-C software in core physics analysis of CNP650 reactor in Hainan Changjiang Nuclear Power Plant,including core refueling scheme analysis,zero power physical test comparison and power operation tracking.The calculation results given by Bamboo-C software conform to the core refueling design criteria,and its performance meets the engineering application requirements of the refueling design of square fuel assembly pressurized water reactor.