CANDU-type reactors operate on-line and without shutdown,suitable for producing short-lie nuclides such as molybdenum-99(99Mo).9 Mo is widely used in China for medicine diagnostics.This paper focuses on 99Mo production study in CANDU reactors with softwares of WIMS-AECL and RFSP-IST.Design and in-core neurotics behavior analysis of the 99Moproducing fuel bundle based on standard bundle are investigated.Results show that 99Moproducing fuel bundle with fuel separated by high and low enrichment fuel in the radial direction almost has the same reactivity and power with the standard bundle.CANDU reactor loading this kind of 99Moproducing bundle also has little changes with standard CANDU reactor.Neurotic's behavior analysis show the potential use of 99Mo production in existing China CANDU-type reactors.