目的:通过Meta分析评价癫痫患者参与运动锻炼的干预效果,为临床实践提供循证依据.方法:系统检索PubMed、Embase、Cochrane Library、Web of Science、中国生物医学文献数据库、中国知网、万方和维普数据库中关于癫痫患者参与运动锻炼的随机对照试验,检索时限为建库至2023年9月29 日,采用RevMan 5.4软件进行Meta分析.结果:纳入9篇文献,共400例患者.Meta分析结果显示,运动锻炼可降低患者癫痫发作频率[MD=-2.35,95％CI(-3.16,-1.54),P＜0.001],未增加不良事件发生[RR=2.54,95％CI(0.11,56.25),P=0.56],可提高患者每日活动量[MD=1.39,95％CI(0.48,2.29),P=0.003],改善患者抑郁症状[SMD=0.90,95％CI(0.22,1.58),P=0.01]、认知功能[SMD=0.69,95％CI(0.03,1.35),P=0.04]和生活质量[SMD=0.43,95％CI(0.22,0.64),P＜0.001].但在改善焦虑症状[SMD=-1.27,95％CI(-3.00,0.46),P=0.15]方面,差异没有统计学意义.结论:癫痫患者执行科学制定的运动锻炼方案具有安全性,且可以有效改善患者抑郁症状、认知功能和生活质量,但对于改善患者焦虑症状效果不显著.
Effects of exercise on patients with epilepsy:a Meta-analysis
Objective:To conduct a Meta-analysis assessing the intervention effects of exercise participation in patients with epilepsy,aiming to provide evidence-based guidance for clinical practice.Methods:We searched randomized controlled trials on epilepsy patients having exercise from PubMed,Embase,Cochrane Library,Web of Science databases,CNKI,Wanfang database,VIP and CBM from their inception to September 29,2023.Meta-analysis was performed by RevMan 5.4.Results:A total of 9 studies involving 400 patients were finally included.The results showed that exercise reduced seizure frequency[MD=-2.35,95％CI(-3.16,-1.54),P＜0.001],without an increased occurrence of adverse events[RR=2.54,95％CI(0.11,56.25),P=0.56].Furthermore,it could enhance the daily activity levels of patients[MD=1.39,95％CI(0.48,2.29),P=0.003],ameliorate depressive symptoms[SMD=0.90,95％CI(0.22,1.58),P=0.01],improve cognitive function[SMD=0.69,95％CI(0.03,1.35),P=0.04],and elevate the quality of life[SMD=0.43,95％CI(0.22,0.64),P＜0.001].However,there was no statistically significant difference in improving anxiety symptoms[SMD=-1.27,95％CI(-3.00,0.46),P=0.15].Conclusion:The implementation of a scientifically developed exercise in patients with epilepsy was safe and effective in relieving depressive symptoms,improving cognitive function and life quality,but was not that obvious in reducing their anxiety symptoms.
万方数据
维普
