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运动干预对系统性红斑狼疮患者生活质量影响的Meta分析

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目的:针对不同运动方案对系统性红斑狼疮患者生活质量改善效果进行Meta分析,为系统性红斑狼疮患者的精准运动指导提供依据.方法:按照PICOS原则,在国内外相关数据库中检索从建库至 2023 年11月发表的运动干预对系统性红斑狼疮患者生活质量影响的实验性或类实验性研究,按照澳大利亚JBI循证卫生保健中心于2016 年发布的干预性研究文献质量评价工具评价.应用RevMan 5.4 进行分析.结果:纳入 9 篇文献进行Meta分析,共529 例研究对象,运动方案包括有氧运动及抗阻运动,亚组分析结果显示,运动频率≥3 次/周的患者在生活质量躯体健康领域[SMD=0.69,95%CI(0.48,0.90),P<0.001]及心理健康领域[SMD=0.90,95%CI(0.45,1.35),P<0.001]改善更为显著;单次运动时长为30~50 min的患者在生活质量躯体健康领域[SMD=0.72,95%CI(0.41,1.04), P<0.001]及心理健康领域[SMD=0.81,95%CI(0.36,1.26), P<0.001]改善更为显著.结论:每周运动≥3 次,每次锻炼持续 30~50 min的患者生活质量改善更显著.建议未来研究进一步规范红斑狼疮患者精准运动方案,以提高患者生活质量.
Exercise intervention on the quality of life in patients with Systemic Lupus Erythematosus:a Meta-analysis
Objective:To evaluate the effect of different exercise programs on the quality of life of patients with Systemic Lupus Erythematosus(SLE).Methods:According to the PICOS principle,an experimental study on the impact of exercise intervention on the quality of life of SLE patients published before November 2023 was retrieved from Chinese and English databases.The study was evaluated by the literature quality evaluation tool published by the Australian JBI Evidence Based Health Center.RevMan 5.4 was applied for data analysis.Results:Nine studies with 529 subjects were included exercise program was classified into aerobic exercise and resistance exercise.Subgroup analysis showed that patients exercised≥3 times per week had significant improvements in quality of life including physical health[SMD=0.69,95%CI(0.48,0.90),P<0.001]and mental health[SMD=0.90,95%CI(0.45,1.35),P<0.001].Patients exercised 30-50 minutes each time showed significant improvements in Quality of Life including physical health[SMD=0.72,95%CI(0.41,1.04),P<0.001]and mental health[SMD=0.81,95%CI(0.36,1.26),P<0.001].Conclusion:SLE Patients who exercise≥3 times a week for about 30-50 minutes each time have a significant improvement in their quality of life.Further large-scale high-quality RCT studies are needed to elucidate the precise exercise plan for patients with SLE.

Systemic Lupus Erythematosusexercise interventionquality of lifeMeta-analysis

程蕾、孙静、连冬梅、王菲

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中国医学科学院北京协和医院儿科,100730 北京市

北京协和医学院护理学院

系统性红斑狼疮 精准运动干预 生活质量 Meta分析

2024

中国护理管理
卫生部医院管理研究所

中国护理管理

CSTPCD北大核心
影响因子:2.545
ISSN:1672-1756
年,卷(期):2024.24(8)