Effects of high-intensity interval training in patients with non-alcoholic fatty liver disease:a Meta-analysis
Objective:To systematically evaluate the effects of high-intensity interval training on patients with non-alcoholic fatty liver disease.Methods:A systematic and comprehensive literature search was conducted for randomized controlled trials examining the effects of high-intensity interval training in patients with non-alcoholic fatty liver disease in PubMed,Cochrane Library,Embase,Web of Science,CINAHL,CNKI,WanFang Data,VIP,and SinoMed.The search timeframe was from the establishment of the databases to November 1,2023.Meta-analysis was performed using RevMan 5.4 software after 2 researchers independently screened the literature,extracted relevant information and quality assessment.Results:Fourteen papers with a total of 598 patients with non-alcoholic fatty liver disease were finally included.Meta-analysis results showed that high-intensity interval training was effective in reducing visceral fat[MD=-7.84,95％CI(-13.19,-2.50),P=0.004]and improving liver function(ALT)[MD=-4.99,95％CI(-6.31,-3.67),P＜0.001],(AST)[MD=-2.63,95％CI(-3.79,-1.47),P＜0.00l],and improving quality of life[MD=0.98,95％CI(0.78,1.18),P＜0.001]and peak oxygen uptake[SMD=1.51,95％CI(0.77,2.24),P＜0.001].The effects of high-intensity interval training on LDL cholesterol,total cholesterol,and triglycerides were statistically significant,while the effect on HDL cholesterol was not significant[MD=-2.71,95％CI(-0.22,5.65),P=0.070].Conclusion:High-intensity interval training can reduce visceral fat,increase peak oxygen uptake,improve cardiopulmonary function,and enhance the quality of life of patients with nonalcoholic fatty liver.However,further research is needed to improve patients'high-density lipoprotein cholesterol.
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