Effects of different doses of TSH inhibition therapy on bone mineral density and serum Tg and MIP-1α in patients with perimenopausal thyroid cancer after operation
Objective To explore the effects of different doses of Thyroid Stimulating Hormone(TSH)inhibition therapy on bone mineral density and serum thyroglobulin(Tg)and Macrophage Inflammatory Protein-1 alpha(MIP-1α)in patients with perimenopausal thyroid cancer after operation.Methods A total of 110 patients with perimenopausal thyroid cancer who were treated in our hospital from Sep 2021 to Jul 2023 retrospectively selected as the study subjects.According to different TSH treatment doses,the patients were divided into high-dose group and low-dose group,with 55 patients in each group.After treatment,the curative effect of the two groups were observed and evaluated.The levels of free triiodothyronine(FT3),free thyroxine(FT4),TSH,Tg,carcinoembryonic antigen(CEA),MIP-1α,calcium,phosphorus and bone mineral density were compared between the two groups.Results The total effective rate of clinical efficacy was 87.27%significantly higher than the 70.91%in the high-dose group(P＜0.05).After treatment,the level of TSH was significantly decreased,and the high-dose group was significantly lower than the low-dose group(P＜0.05);The levels of FT3 and FT4 were increased,and the high-dose group was higher than the low-dose group(P＜0.05);The levels of serum Tg,CEA and MIP-1α in the high-dose group were significantly lower than those in the low-dose group(P＜0.05).There was no significant change in the levels of calcium,phosphours and bone mineral density after treatment(P＞0.05).Conclusion High-dose TSH inhibition therapy surpasses low-dose TSH treatment in effectively suppressing TSH secretion,leading to indirect reduvtions in serum.Tg and MIP-1α levels.Both therapies have no significant effect on patient bone metabdism.
TSH inhibition therapyPerimenopausalThyroid cancerBone mineral densitySerum thyroglobulinMacrophage inflammatory protein-1α
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