The relationship between HDL-C and CRP levels and cardiac function and vulnerable plaques in patients with coronary heart disease complicated with heart failure
Objective To investigate the relationship between the changes in serum high-density lipoprotein cholesterol(HDL-C)and C-reactive protein(CRP)levels and clinical heart function grade and vulnerable plaque in patients with coronary heart disease(CHD)complicated with heart failure(HF).Methods 103 patients with CHD complicated with HF admitted to our hospital from Jan 2021 to Jun 2023 were selected,and the serum HDL-C and CRP were measured by direct measurement and immunoturbidimetry.Patients were classified into gradesⅠ～Ⅱ,gradeⅢand grade Ⅳaccording to the American Heart Association(NYHA);all patients underwent optical coherence tomography(OCT)examination,and divided into vulnerable and stable groups based on the plaque properties.and compared the changes in serum HDL-C and CRP with different functional levels and plague properties.The Spearman correlation analysis was used to analyze the correlation between serum HDL-C、CRP,heart function grading,and rulnerable coronary artery plagues in patients with CHD complicated with HF.Results Significant variations were observed in serum HDL-C and CRP levels across different heart function grades(P＜0.05).Specifically,HDL-C levels exhibited a decreasing trend from gradeⅠtoⅡ＞gradeⅢ＞gradeⅣ(P＜0.05),while CRP levels demonstrated and increasing trend from gradeⅠtoⅡ＜gradeⅢ＜grade Ⅳ(P＜0.05).In the vulnerable group,serum HDL-C was lower than that in the stable plague group(P＜0.05),and CRP levels were higher(P＜0.05).Spearman correlation analysis indicated a negative correlation between serum HDL-C levels and cardiac function grade as well as vulnerable plaque(r=-0.758,-0.788,P＜0.05),while serum CRP levels showed a positive correlation with cardiac function grade and vulnerable plaque(r=0.883,0.862,P＜0.05).Conclusion Serum levels of HDL-C and CRP in patients with CHD complicated by HF exhibit a significant correlation cardiac function grade and vulnerable plaque occurrence.Lower HDL-C levels correspond to higher CRP levels,indicating a heightened degree of the cardiac function impairment and the risk of plaque vulnerability.
Coronary heart disease complicated with heart failureHigh density lipoprotein cholesterolCreactive proteinCardiac functionVulnerable plaqueCorrelation
万方数据
维普
