A correlation study between the novel immune/inflammatory index and frailty in elderly patients with coronary heart disease undergoing percutaneous coronary intervention treatment
Objective To explore the correlation between novel immune/inflammatory indexes such as PLR,MLR,SII,SIRI and preoperative frailty in elderly patients with coronary heart disease undergoing PCI,and their predictive value for preoperative frailty in elderly patients with coronary heart disease undergoing PCI.Methods A total of 319 elderly coronary heart disease patients who underwent PCI in the First Affiliated Hospital of Shihezi University from Dec 2021 to May 2023 were selected.The FRAIL scale was used to evaluate patients and divide them into non frailty group and frailty group.Collected general clinical and laboratory data of patients,and calculated PLR,MLR,SII,and SIRI.Compared the baseline data of two groups and analyzed the relevant factors for preoperative frailty in elderly patients with coronary heart disease undergoing PCI.Finally,the predictive values of PLR,SII and SIRI for preoperative frailty were analyzed through ROC curve analysis.Results There were 201 cases(63.0%)in the non frail group and 118 cases(37.0%)in the frail group.PLR,MLR,SII and SIRI levels were all positively correlated with FRAIL scores(P<0.05).Univariate logistic regression analysis showed that PLR,SII,SIRI were all associated with preoperative frailty in elderly patients with coronary heart disease undergoing PCI(P<0.05).Multivariate logistic regression analysis showed that SII was still correlated with preoperative frailty in elderly patients with coronary heart disease undergoing PCI(OR=1.001,95%CI:1.000～1.002,P=0.031).The area under the ROC curve(AUC)of PLR,SII and SIRI in predicting the risk of preoperative frailty in elderly patients with coronary heart disease undergoing PCI were 0.665,0.723 and 0.640,respectively,with SII having the highest AUC value(P<0.001).Conclusion For elderly patients with coronary heart disease undergoing PCI,PLR,SII and SIRI have certain predictive value for preoperative frailty.SII is an independent related factor and is expected to become an indicator for predicting the risk of preoperative frailty.
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