Objective To observe the correlation between mitochondrial aspartate aminotransferase(mAST)/alanine aminotransferase(ALT)and the survival time of patients with severe fever and thrombocytopenia syndrome(SFTS),and explore its application value in diagnosing the prognosis of patients with SFTS.Methods 317 patients with SFTS diagnosed in our hospital from Jan 2021 to Jan 2023 were selected,and the clinical characteristics of all SFTS patients and survivors and deaths admitted to intensive care unit(ICU)were compared within one week after admission.Logistic multiple regression was used to analyze the independent death risk factors of all SFTS patients and patients admitted to ICU,and the application value of mAST/ALT in prognosis evaluation of SFTS patients was analyzed.Results The average age and level of ALP,AST,ALT,AST/ALT,cytoplasmic aspartate aminotransferase(cAST),cAST/ALT,mAST,mAST/ALT,CK-MB,creatine kinase(CK),GGT,and α-hydroxybutyrate dehydrogenase(α-HBDH)in the death group were higher than those in the survival group(P<0.05).And age,levels of AST,cAST,AST/ALT,cAST/ALT,mAST/ALT,CK and α-HBDH of the dead patients in ICU were significantly higher than those in the survivors(P<0.05).Logistic multiple regression analysis showed that age,α-HBDH,AST/ALT,cAST/ALT and mAST/ALT were the independent risk factors for death in all SFTS patients(P<0.05),while the AST/ALT,cAST/ALT and mAST/ALT were independent risk factors for mortality in ICU patients(P<0.05),and the OR value of mAST/ALT was the highest.Drawn ROC curve,the AUC values of the above parameters were all greater than 0.7,which had certain predictive value,and mAST/ALT had the highest specificity and sensitivity,with the best prognostic predictive value.Conclusion The levels of AST/ALT,cAST/ALT and mAST/ALT are related to the prognosis of patients with SFTS,with the level of mAST/ALT has the prognostic value for patients with severe SFTS.
Fever with thrombocytopenia syndromeMitochondrial aspartate aminotransferaseAlanine transaminaseRisk factorsprognosis
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