Risk factors of nosocomial MRSA infection in severe burn patients and clinical efficacy evaluation of linezolid
Objective To invesigate the risk factors for methicillin-resistant Staphylococcus aureus(MRSA)infection in hospitals with severe burns and evaluate the efficacy of linezolid.Methods A total of 152 cases of severe burn patients from the department burns in our hospital from May 2022 to Feb 2023 were selected,patients with MRSA infection were divided into infection group and patients with MSSA infection were divided into control group,76 cases in each group.The general data of patients were analyzed.The patients in the infection group were divided into low-dose group and high-dose group with 38 cases in each group according to different doses of linezolid treatment,and the clinical efficacy and adverse reactions of patients were compared.Results The use time of antibiotics,third-degree burn and the time of medical staff's invasive operation during the treatment of patients had an impact on the occurrence of nosocomial MRSA infection in patients with severe burn,with significant differences(P<0.05).The age of patients,the type of invasive operation,the number of pathogenic bacteria,gender,the number of operations and dressing changes had little effect on MRSA infection,and there was no significant difference(P>0.05).The correlative analysis showed the use time of antibiotics,third-degree burn and the time of invasive operation had a positive correlation with the occurrence of nosocomial MRSA infection in patients with severe burn(P<0.05).Logistic analysis showed that third-degree burns,use time of antibiotics,time of invasive operations were dangerous factors of MRSA infection in the severe burn room.In contrast,the clinical outcomes of patients with high doses of linezolid were significantly better than those with low doses(P<0.05).The incidence of adverse reactions in the low dose group was significantly lower than that in the high dose group(P<0.05).Conclusion The use time of antibiotics,third-degree burn and the time of invasive operation are the risk factors of nosocomial infection of MRSA in patients with severe burn.The high dose of linezolid is more effectively,but with higher occurrence rate of side effects.
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