Expression levels of cholesterol acyltransferase 1 in non-small cell lung cancer patients and its relationship with tumor stage and pathological grade
Objective To study the expression levels of cholesterol acyltransferase 1(ACAT1)in non-small cell lung cancer(NSCLC)patients and its relationship with tumor stage and pathological grade.Methods Cancer tissue specimens from 58 NSCLC patients from Jan 2022 to Jan 2024 were selected as the research group,and 20 pericancerous tissue specimens of them were randomly selected as the control group.The expression levels of ACAT1 mRNA were compared between the two groups and analyzed in relationship to tumor stage and pathological grade.Results The ACAT1 mRNA expression levels varied significantly between the research group and control groups(P<0.05).There was no significant difference in age,gender or smoking history between the high and low expression groups(P>0.05).The high and low expression groups showed significant differences in tumor size,lymph node metastasis and distant metastasis(P<0.05).There were statistically significant differences in tumor stage and pathological grade between the high and low expression group(P<0.05).ACAT1 mRNA expression levels positively correlated with tumor stage and pathological grade(P<0.05).There was a significant corcorrelation between ACAT1 mRNA expression and tumor size,lymph node metastasis,distant metastasis,tumor stage and pathological grade(P<0.05).Conclusion The expression level of the ACAT1 mRNA in NSCLC is closely related to tumor stage and pathological grade.
Cholesterol acyltransferase 1Non small cell lung cancerExpression levelTumor stagePathological grade
万方数据
维普
