The investigation of the relationship between osteoporosis and intervertebral disc degeneration through Mendelian randomization study
Objective To investigate the causal relationship between intervertebral disc degeneration(IVDD)and osteoporosis by the two-sample Mendelian randomization(MR)study.Methods The analysis was conducted by the data obtained from gene-wide association studies(GWAS).Multiple methods,primarily with inverse variance weighted(IVW)approach,were employed for Mendelian randomization study.Sensitivity analysis,heterogeneity testing and multi-effect analysis were performed.In addition,instrumental variable(IV)analysis was conducted by the F-value statistic.Results The MR results indicated:femoral neck bone mineral density(BMD),lumbar spine BMD and heel BMD had directly causal effect on IVDD.Femoral BMD-related analysis,OR(95%CI):1.097(1.009～1.193),P=0.028;lumbar BMD-related analysis,OR(95%CI):1.176(1.104～1.253),P<0.0001;heel BMD-related analysis,OR(95%CI):1.057(1.006～1.112),P=0.028.Forearm BMD had no causal effect on IVDD,OR(95%CI):1.000(0.949～1.053),P=0.992.The reverse MR analysis showed,there was no evidence for causal association of BMD on IVDD.Conclusion Patients with osteoporosis have an increased risk of IVDD,and intervertebral disc degeneration is not causally related to osteoporosis.
Intervertebral disc degenerationMendelian randomizationOsteoporosisBone mineral density
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