首页|Copper(I)-Catalyzed Interrupted Click/Sulfenylation Cascade: One-Pot Synthesis of Sulfur Cycle Fused 1,2,3-Triazoles

Copper(I)-Catalyzed Interrupted Click/Sulfenylation Cascade: One-Pot Synthesis of Sulfur Cycle Fused 1,2,3-Triazoles

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Herein,we report a practical protocol for the synthesis of sulfur cycle fused 1,2,3-triazoles through a copper(I)-catalyzed tandem click/intramolecular sulfenylation reaction.The reaction proceeded via a copper-catalyzed alkyne azide cycloaddition,followed by interception of the in situ formed cuprate-triazole intermediate with p-toluenesulfonothioate.This reaction shows broad substrate scope,complete regioselectivity,and excellent functional group tolerance under mild reaction conditions.

Weiguo Wang、Shuai Huang、Shikun Yan、Xuejun Sun、Chen-Ho Tung、Zhenghu Xu

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School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu, Shandong 273165, China

Key Lab for Colloid and Interface Chemistry of Education Ministry, Shandong University, Jinan, Shandong 250100, China

State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

We are grateful for financial support from the Natural Science Foundation of China and Shandong ProvinceWe are grateful for financial support from the Natural Science Foundation of China and Shandong ProvinceWe are grateful for financial support from the Natural Science Foundation of China and Shandong ProvinceWe are grateful for financial support from the Natural Science Foundation of China and Shandong ProvinceTang scholar award and the Fundamental Research Funds of Shandong University

Nos.2157211821971149ZR2018MB014ZR2019ZD45

2020

中国化学(英文版)
中国化学会 上海有机化学研究所

中国化学(英文版)

CSTPCDCSCDSCI
影响因子：0.848
ISSN：1001-604X
年,卷(期)：2020.5(5)
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