Dcalycinumines A-E,Alkaloids with Cytotoxic Activities of Nasopharyngeal Carcinoma Cells from Daphniphyllum calycinum

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外文摘要：Five novel Daphniphyllum alkaloids,named dcalycinumines A-E(1-4,6),and eight previously described Daphniphyllum alkaloids(5,7-13)were isolated from Daphniphyllum calycinum.Compound 1 is the first Daphniphyllum alkaloid possessing a highly rearranged 6/6/6/7/5/6 hexacyclic architecture with a unique 3-methyl-1-azabicyclo[4,4,0]decane ring system.Compound 2 represents a rare diamino Daphniphyllum alkaloid with an unprecedented 6/5/5/6/6/5 carbon skeleton featuring a unique 1-aza-6-azaspiro[4,5]decane unit,whereas 3 also represents a rare diamino Daphniphyllum alkaloid as a possible precursor of 2.Compound 4 is the second exam-ple of C-22-nor yuzurimine-type alkaloids.Their structures and absolute configurations were elucidated by HRESIMS,NMR spectro-scopic analyses,ECD calculations,and single-crystal X-ray diffraction.Moreover,compound 1 showed remarkable antitumor activities,which could inhibit the proliferation,migration and invasion of nasopharyngeal carcinoma cells,and promoted nasopharyngeal carci-noma cells apoptosis.

外文关键词：

Daphniphyllum calycinumNatural productsDaphniphyllum alkaloidStructural elucidationBiological activityApoptosisNasopharyngeal carcinoma

作者：

Qing Tang、Xiao-Yong Dai、Qiang Lin、Zhi-Peng Ling、Yi-Kun Hao、Tian-Xi Zhu、Ji-Hui Zhang、Yi-Bo Hou、Yao-Lan Li、Lai-Qiang Huang、Jing-Hao Wang、Guo-Cai Wang、Yu-Bo Zhang

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作者单位：

Institute of Traditional Chinese Medicine & Natural Products,Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research,College of Pharmacy,Jinan University,Guangzhou,Guangdong 511443,China

Institute of Biopharmaceutical and Health Engineering,Shenzhen Key Laboratory of Gene and Antibody Therapy,State Key Laboratory of Chemical Oncoge()mics,Shenzhen International Graduate School,Tsinghua University,Shenzhen,Guangdong 518055,China

The Guangzhou Key Laboratory of Basic and Translational Research on Chronic Disease,Department of Pharmacy,The First Affiliated Hospital,Jinan University,Guangzhou,Guangdong 510630,China

Guangdong Clinical Translational Center for Targeted Drug,Department of Pharmacology,School of Medicine,Jinan University,Guangzhou,Guangdong 510632,China

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基金：

国家自然科学基金国家自然科学基金国家自然科学基金国家自然科学基金Guangdong Basic and Applied Basic Research Foundation广州市科技计划Analytical and Testing Center of Jinan UniversityHigh Performance Public Computing Service Platform of Jinan University

项目编号：

821736958227380382003743819731902020B1515020033202201010485

出版年：

2024

DOI：

10.1002/cjoc.202300442

中国化学(英文版)

中国化学会上海有机化学研究所

中国化学(英文版)

CSTPCD

影响因子：0.848

ISSN：1001-604X

年,卷(期)：2024.42(1)

参考文献量22