首页|Cationic Conjugated Oligomers for Efficient and Rapid Antibacterial Photodynamic Therapy via Both Type Ⅰand Type Ⅱ Pathways

Cationic Conjugated Oligomers for Efficient and Rapid Antibacterial Photodynamic Therapy via Both Type Ⅰand Type Ⅱ Pathways

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Recently,photodynamic therapy(PDT)has attracted wide attention due to its less susceptibility to drug resistance,broad-spectrum biocidal activity and biosafety in normal tissues.However,the traditional photosensitizers(PSs)face the disadvantage of poor thera-peutic efficacy due to the requirement of an aerobic environment to generate 1O2 through Type Ⅱ pathway.Herein,we designed and synthesized a novel cationic conjugated oligomer oligo(phenylene vinylene)(OPV)and studied its antibacterial photodynamic activity against both Gram-negative Escherichia coli(E.coli)and Gram-positive bacteria methicillin-resistant Staphylococcus aureus(MRSA).Importantly,the OPV can rapidly produce reactive oxygen species(ROS)through double pathways,Type Ⅰ and Ⅱ mechanism under white light irradiation,and efficiently kill E.coli and MRSA at a nanomolar level.The dual type photosensitizing capability makes OPV promising for enhanced PDT to treat pathogens and tumors in complex environments.

Conjugated oligomersAntibacterial photodynamic therapyOligo(phenylene vinylene)Reactive oxygen speciesType Ⅰ and Ⅱ pathways

Huan Wang、Shuwen Guo、Qiong Yuan、Meiqi Li、Yanli Tang

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Country Key Laboratory of Analytical Chemistry for Life Science of Shaanxi Province,Key Laboratory of Applied Surface and Colloid Chemistry,Ministry of Education,School of Chemistry and Chemical Engineering,Shaanxi Normal University,Xi'an,Shaanxi 710119,China

国家自然科学基金国家自然科学基金国家自然科学基金Innovation Capability Support Program of Shaanxi中央高校基本科研业务费专项中央高校基本科研业务费专项中央高校基本科研业务费专项

2197408422274095221013102021TD-42GK202302004GK202207013GK202101001

2024

10.1002/cjoc.202300447

中国化学(英文版)
中国化学会 上海有机化学研究所

中国化学(英文版)

CSTPCD
影响因子：0.848
ISSN：1001-604X
年,卷(期)：2024.42(1)
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