首页|Phosphine-Catalyzed[4+3]Annulation Reaction of Indole Derivatives with MBH Carbonates:A Facile Access to Indole-1,2-fused 1,4-Diazepinones and Azepines

Phosphine-Catalyzed[4+3]Annulation Reaction of Indole Derivatives with MBH Carbonates:A Facile Access to Indole-1,2-fused 1,4-Diazepinones and Azepines

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A phosphine-catalyzed[4+3]annulation between dinucleophilic indole derivatives and Morita-Baylis-Hillman(MBH)carbonates was discovered by using the N1 and N4'/C4'nucleophilicities of the indole precursors,in which indoles act as four atom synthons.This protocol provides an efficient and facile access to indole-1,2-fused 1,4-diazepinones and azepines in good to high yields in one step,which illustrates potential synthetic utilities in drug discovery.

Phosphine catalysis[4+3]AnnulationIndole derivativesNitrogen heterocyclesOrganocatalysis

Yannan Zhu、Haoran Jiang、Yi-Ning Wang

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Faculty of Chemistry and Chemical Engineering,Yancheng Institute of Technology,Yancheng,Jiangsu 224051,China

funding for schoollevel research projects of Yancheng Institute of Technologyfunding for schoollevel research projects of Yancheng Institute of Technology

XJR2022019XJ201719

2024

10.1002/cjoc.202300505

中国化学(英文版)
中国化学会 上海有机化学研究所

中国化学(英文版)

CSTPCD
影响因子：0.848
ISSN：1001-604X
年,卷(期)：2024.42(3)
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