首页|Nickel-Catalyzed Stereoselective Migratory Carboboration of 1,4-Cyclohexadiene
Nickel-Catalyzed Stereoselective Migratory Carboboration of 1,4-Cyclohexadiene
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Multi-substituted cyclohexanes play a crucial role as scaffolds in bioactive compounds.While significant progress has been made in synthesizing substituted cyclohexanes,methods for the stereoselective assembly of 1,3-disubstituted cyclohexanes remain scarce.This study presents a novel approach involving nickel catalysis to achieve stereoselective carboboration of 1,4-cyclohexadiene.This innova-tive process allows for the simultaneous introduction of a boron group and an aryl or an alkyl fragment into the 1,4-cyclohexadiene framework under mild conditions,with exclusive regioselectivity and excellent cis configuration.The resulting products feature a dou-ble carbon bond and the incorporation of the boron group,offering significant potential for subsequent transformations and down-stream applications.
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