Palladium-Catalyzed anti-Markovnikov Halosulfonamidation of Unactivated Alkene

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外文摘要：Palladium-catalyzed regioselective amination of unactivated alkene remains a challenge and is of great interest.Herein,a three-component coupling of unactivated alkene,sulfonamide,and N-halo compounds accessing vicinal haloamine has been con-ceived.This aminohalogenation represents a modular and regioselective strategy.The electrophilic halogenating agent enables regi-oselective anti-Markovnikov aminopalladation and facilitates subsequent halogenation events.And this protocol is characterized by gram-scale syntheses and late-stage functionalizations.Of note,the recovered byproduct phthalimide allows for reusing by conver-sion to the starting material.

外文关键词：

Unactivated alkeneanti-Markovnikov aminopalladationVicinal haloaminePalladium catalysisHalosulfonamidationSelectivityN-Halo compounds

作者：

Bowen Wang、Jianxiao Li、Wanqing Wu、Huanfeng Jiang

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作者单位：

State Key Laboratory of Pulp and Paper Engineering,Key Laboratory of Functional Molecular Engineering of Guangdong Province,School of Chemistry and Chemical Engineering,South China University of Technology,Guangzhou,Guangdong 510641,China

基金：

国家自然科学基金国家自然科学基金Key-Area Research and Development Program of Guangdong Province

项目编号：

22231002218710952020B010188001

出版年：

2024

DOI：

10.1002/cjoc.202300601

中国化学(英文版)

中国化学会上海有机化学研究所

中国化学(英文版)

CSTPCD

影响因子：0.848

ISSN：1001-604X

年,卷(期)：2024.42(5)

参考文献量55