首页|Efficient Photolytic Halogenation and Oxidation of Unactivated Alkyl sp3 C—H Bonds with lodine(Ⅲ)

Efficient Photolytic Halogenation and Oxidation of Unactivated Alkyl sp3 C—H Bonds with lodine(Ⅲ)

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A metal-free,green,and sustainable functionalization of unactivated alkyl sp3 C—H bonds is reported using iodine(Ⅲ)as a feasible dehydrogenation agent under visible light or KBr,and alkyl chlorides,bromides,alcohols,and ketones could be constructed by addi-tion of different coupling reagents.Cheap and safe iodobenzene diacetate was used to form a radical to activate the alkyl sp3 C—H bond in a highly efficient manner,which can construct different alkylation products by adding corresponding coupling reagents.

Alkyl sp3 C—H bondsChlorinationBrominationOxidationIodine(Ⅲ)C—H activationRadicalPhotocatalysis

Hao Jia、Nan Li、Chunmei Tang、Yajuan Wang、Yonghao Xi、Rongbao Liao、Wei Xu、Fufang Wu、Xiaobao Shen、Hongbin Zhai

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Biomass Oligosaccharides Engineering Technology Research Center of Anhui Province,Engineering Research Center of Biomass Conversion and Pollution Prevention of Anhui Educational Institutions,Fuyang Normal University,Fuyang,Anhui 236037,China

Institute of Marine Biomedicine,Shenzhen Polytechnic,Shenzhen,Guangdong 518055,China

State Key Laboratory of Chemical Oncogenomics,Shenzhen Engineering Laboratory of Nano Drug Slow-Release,Peking University Shenzhen Graduate School,Shenzhen,Guangdong 518055,China

Natural Science Foundation of Higher Education Institutions in Anhui ProvinceNatural Science Foundation of Higher Education Institutions in Anhui Province国家自然科学基金国家自然科学基金深圳市科技计划深圳市科创委项目Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research InstitutionsHorizontal Cooperation Project of Fuyang Municipal GovernmentKey Projects of the Support Program for Outstanding Young Talents in Anhui Province Colleges and UniversitiesYifan Pharmaceutical Co.,LtdInnovative Drug Design & Development Collaborative Team

2022AH0301332022AH0513402223100322271008KQTD20190929174023858GXWD20201231165807007-202008121001150012023SHIBS0004SXHZ202201gxyqZD2020030HX2019033TDYY2021009

2024

10.1002/cjoc.202300544

中国化学(英文版)
中国化学会 上海有机化学研究所

中国化学(英文版)

CSTPCD
影响因子：0.848
ISSN：1001-604X
年,卷(期)：2024.42(5)
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