Cooperative NHC/Photoredox Catalysis:Three-Component Reaction of Aroyl Fluorides,Styrenes and Oxalates

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外文摘要：Cooperative NHC/photoredox catalysis has emerged as an important research field in recent years.Herein,this article describes the use of cesium salt derivatives of tert-alcohols as alkyl radical precursors in a three-component reaction with styrene and aromatic acyl fluorides to synthesize α-arylalkyl aryl ketones.The aroyl fluoride reacts with the NHC catalyst,leading to the formation of an acyl az-olium ion.This acyl azolium ion can then be reduced by the photoredox catalyst,generating the corresponding ketyl radical anion.The C-radical generated from oxalate oxidation undergoes an addition reaction with the styrene derivative,followed by cross-coupling of the addition radical with the ketone radical,which is fragmented by NHC to give the target ketone.

外文关键词：

Three-componentPhotoredoxNHCAryl ketonesIridiumRadicalC-C couplingAmides

作者：

Zheng Lin、Guanghui Lv、Jianghong Liu、Jiangyan Tang、Binsong Mu、Jian Chen、Tianle Huang、Zhongzhen Yang、Yong Wu

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作者单位：

Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province,Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology,West China School of Pharmacy,Sichuan University,Chengdu,Sichuan 610041,China

Department of Pharmacy,Hubei Provincial Clinical Research Center for Umbilical Cord Blood Hematopoietic Stem Cells,Taihe Hospital,Hubei University of Medicine,Shiyan,Hubei 442000,China

基金：

四川省科技计划

项目编号：

2020YJ0221

出版年：

2024

DOI：

10.1002/cjoc.202300524

中国化学(英文版)

中国化学会上海有机化学研究所

中国化学(英文版)

CSTPCD

影响因子：0.848

ISSN：1001-604X

年,卷(期)：2024.42(5)

参考文献量25