首页|Nickel-Catalyzed Regiodivergent Acylzincation of Styrenes with Organozincs and CO
Nickel-Catalyzed Regiodivergent Acylzincation of Styrenes with Organozincs and CO
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Transition metal-catalyzed carbometallation of unsaturated hydrocarbons constitutes one of the most efficient synthetic methodolo-gies for the construction of C-C bond.Recently,the incorporation of organometallic reagent with the CO gas as a nucleophilic acyl synthon could enable the acylmetallation reaction,which greatly increases the horizon of carbometallation chemistry.Herein,we re-port a nickel-catalyzed regiodivergent acylzincation of o-cyano cinnamate ester and o-cyano styrene,in which the cyano moiety intra-molecularly captures zinc intermediates to trigger the tandem cyclization process.This protocol features mild conditions,broad sub-strate scope and excellent functional group tolerance,thus affording a diverse array of highly functionalized carbocyclic compounds.
Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering,Feringa Nobel Prize Scientist Joint Research Center,Frontiers Science Center for Materiobiology and Dynamic Chemistry,School of Chemistry and Molecular Engineering,East China University of Science and Technology,Shanghai 200237,China
国家自然科学基金国家自然科学基金上海市自然科学基金Shanghai Rising-Star ProgramShanghai Sailing Program上海市科技计划重大项目Program of Introducing Talents of Discipline to Universities中国博士后科学基金中国博士后科学基金中央高校基本科研业务费专项
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